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Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy

Comparison of Two Strategies for Blood Pressure Control in the Setting of Acute Ischemic Stroke to Reduce Cerebral Hemorrhage After Thrombectomy: Systolic Blood Pressure Target of Less Than 130 mmHg vs Less Than 185 mmHg, for 24 Hours Following Reperfusion, in Patients With Cerebral Infarction Due to Occlusion of the Anterior Circulation

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03160677
Acronym
BP-TARGET
Enrollment
320
Registered
2017-05-19
Start date
2017-06-21
Completion date
2020-01-31
Last updated
2021-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Stroke, Blood Pressure, Cerebral Hemorrhage

Keywords

Acute Stroke, Blood Pressure, Cerebral Hemorrhage

Brief summary

A randomized, multicenter study comparing two strategies: 1 / standard management of systolic blood pressure according to international recommendations (systolic blood pressure \<185 mm Hg) versus 2 / intensive blood pressure management Systolic with a target \<130 mm Hg.

Detailed description

Patients will be followed for 3 months: * inclusion after reperfusion: clinical evaluation with NIHSS (National Institute of Health Stroke Score) score, measurement of blood pressure. * within 24 hours after reperfusion: blood pressure measurements * at 24 hours: measurement of blood pressure (T0 + 24 h and evaluation of the NIHSS score. * Between 24 and 36 hours :cerebral scan (assessment of hemorrhagic transformations and cerebral infarction volumes). For some centers: Cerebral MRI without injection between H24 and H36 * 72 hours after reperfusion: Cerebral scanner in case of hyperdensity on the initial scanner * 3 months after reperfusion: disability assessment by Rankin score

Interventions

OTHERSystolic blood pressure target < 130 mm Hg

Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 130 mm Hg

OTHERSystolic blood pressure target < 185 mm Hg

Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 185 mm Hg

Sponsors

Fondation Ophtalmologique Adolphe de Rothschild
Lead SponsorNETWORK

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Intracranial Occlusion of internal carotid arteries and/or proximal middle cerebral (segment M1) diagnosis made on initial Imaging. * Reperfusion after a thrombectomy procedure (defined by a 2b-3 TICI score -Thrombolysis In Cerebral Infarction- score).

Exclusion criteria

* Per-procedure hemorrhagic complications (prior to reperfusion) * Systolic blood pressure at baseline \<130 mm Hg within one hour of recanalization * Pre-existing stroke handicap defined by a Rankin score (modified scale, mRS)\> 3 * Hemodynamically significant carotid stenosis * Occlusion of the isolated cervical carotid artery * Known pregnancy * Legal protection * Non-affiliation to a social security scheme * Refusal of the patient (or of his / her relatives in case of urgent inclusion)

Design outcomes

Primary

MeasureTime frameDescription
Rate of patients with intracranial hemorrhagic complicationsScan performed between 24 and 36 hours after thrombectomyRate of patients with intracranial hemorrhagic complications (Symptomatic or asymptomatic) on cerebral scan, evaluated with a double centralized blind reading

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026