Eating Disorder
Conditions
Keywords
Anorexia nervosa, Bulimia, Binge eating disorders, Neuropsychology, Neurocognition, Daily functioning
Brief summary
Eating disorders are multifactorial disorders currently conceptualized in a biopsychosocial model, but pathophysiology remains relatively unknown, and robust etiological models to guide treatment are therefore lacking. Different endophenotypes and neurocognitive vulnerability factors have been found in eating disorders including decision making abnormalities. The investigators hypothesize that decision making abnormalities are associated with a lower level of functioning and quality of life which could lead to social and interpersonal difficulties. The investigators also hypothesize that these anomalies are associated with a particular clinical profile (more restrictive profile, more hyperactivity, less insight on the disease and desire for care ...).
Detailed description
The investigators will recruit a total of 340 patients with an eating disorder in the university hospital of Montpellier. * Participation consists of a one-day visit with a multidisciplinary assessment. No action is specific to research. This is the usual management of patients with eating disorders addressed to our department. * An ancillary study will be proposed, if the patient is addressed by his general practitioner for an annual evaluation. This second visit will be exactly the same as the initial visit.
Interventions
BEHAVIORALAmbulatory cares in a day-hospital (University Hospital of Montpellier) specialized in the evaluation of eating disorders
All patients assessed in the day-hospital will performed the same evaluation : * Blood sampling * Calorimetry * Osteodensitometry * Psychiatric assessment * Endocrinologic assessment * Dietetic assessment * Neuropsychological assessment * Self-questionnaires With the patient agreement, a biological collection will be constituted. The objective is the subsequent study of biological factors involved in eating disorders (in particular genetic factors)
Sponsors
INSERM 1061, Neuropsychiatry: epidemiological and clinical research, Montpellier
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patient with an eating disorder according to Diagnostic and Statistical Manuel of Mental disorders-V (DSM-V) criteria * Patient aged from 15 to 65 years * Patient who performs the day-hospital evaluation * Patient affiliated to a French social security system * Patient able to understand the nature, the aim and the methodology of the study * For minor one of the legal guardians gave his consent
Exclusion criteria
* Patient in an unstable somatic state (eg severe metabolic disorder making impossible or unreliable neuropsychological assessments) * Patient's refusal to participate * Patient on protective measures (guardianship or trusteeship) * Pregnant or nursing women. A dosage of beta human chorionic gonadotropin (βHCG) will be performed to ensure the absence of pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of functional impairment assessed by the Work and Social Adjustment Scale (WSAS) | Baseline | We aim to investigate the link between decision-making and daily functioning of patients with eating disorder. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life assessed by the Eating disorder quality of life (EDQOL) scale. | Baseline | We aim to investigate the link between quality of life and alteration of cognitive flexibility of patients with eating disorder. |
| Level of functional impairment assessed by the clinician with the Functional Assessment Staging Test (FAST) scale | Baseline | We aim to investigate the link between global functioning and alteration of cognitive flexibility of patients with eating disorder. |
| Level of functional impairment assessed by the clinician with the FAST scale | Baseline | We aim to investigate the link between global functioning and alteration central coherence of patients with eating disorder. |
| Score to decision making test (Iowa gambling task) | At 12 months if patient is included in the ancillary study | We aim to investigate the prognostic value of decision making abnormalities on the rates of recovery |
Countries
France
Outcome results
None listed