Hiv
Conditions
Brief summary
The population of inpatients is large in Zambia; however, because of poor linkages between hospitals and community HIV care, there are few data to analyze their engagement in HIV care before and after hospitalization. The goal of the study is to learn more about Zambian adults who are HIV-infected and get hospitalized. The purpose of this study is to gather formative, preliminary data, to be used in future grant applications to improve linkage and engagement in HIV care in Zambia.
Detailed description
The main objective of this study is to generate preliminary data on the outcomes of Zambian HIV-infected individuals after discharge from University Teaching Hospital (UTH) Internal Medicine wards which can inform development of a linkage intervention. Our central hypothesis is that in Sub-Saharan African settings like Zambia hospitalizations among HIV-infected individuals are driven by suboptimal linkage and initiation of ART following HIV diagnosis. Specific Aims: (a) Characterize the distribution of hospitalized 300 HIV-infected adults across the HIV care continuum. (b) Identify structural, psychosocial, clinic, and medical factors that predict suboptimal linkage to care and ART initiation after 90 days of hospital discharge among HIV-infected Zambians.
Interventions
OTHERStandard of care
Routine standard of care per Ministry of Health protocol, including blood draws and examinations.
Sponsors
University Teaching Hospital
Centre for Infectious Disease Research in Zambia
University of Alabama at Birmingham
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 years or older * HIV-infected as documented in the UTH file * Admitted to Internal Medicine Ward at UTH
Exclusion criteria
* Unable to provide informed consent * Not planning to remain in Lusaka province for 3 months after discharge
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Undetectable HIV viral load at 90 days post-discharge | 90 days after hospital discharge | Numerator is number with HIV RNA \<1000 c/mL tested at 90 days after hospital discharge; denominator is the # enrolled |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of HIV-infected inpatients who are on ART upon admission | Baseline | Numerator is number who report taking ART up to the time of admission; denominator is the # enrolled |
| Mortality rate | 90 days after hospital discharge | Mortality from time of enrollment to 90 days after discharge |
| ART initiation | Baseline and 90 days after hospital discharge | Proportion not on ART upon admission to hospital who are on ART at 90 days after hospital discharge |
Countries
Zambia
Outcome results
None listed