Condylomata Acuminata
Conditions
Keywords
DC-CIK, interferon
Brief summary
Cytokine-induced killer (CIK) cells will be co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to Condylomata Acuminata patients using interferon, whose recurrence rate and total cost will be compared to Condylomata Acuminata patients only use interferon.
Interventions
BIOLOGICALDC-CIK immunotherapy
Cytokine-induced killer (CIK) cells are co-cultured with HPV induced dendritic cells (DCs); HPV specific DC-CIK will be induced to condylomata acuminata patients
Sponsors
Shenzhen Second People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
All patients have typical clinical characters of condyloma, positive for HPV-DNA test; All patients have been treated for cryotherapy or laser plus interferon for over half a year without completely recovery. All patients or their family will sign informed consent and approved by Ethics Committee of Shenzhen Second People's Hospital -
Exclusion criteria
pregnant, blood disease, contraindication for immune therapy, allergic to interferon \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Condylomata Acuminata recurrence rate | 6 months | Condylomata Acuminata recurrence rate in 6 months after treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| skin tissue HPV gene | 6 months | use PCR to testify skin tissue HPV gene |
| side effect | 6 months | evaluate and record side effect of each group |
Countries
China
Outcome results
None listed