Xerostomia Due to Hyposecretion of Salivary Gland
Conditions
Keywords
saliva , dental , oral health
Brief summary
The purpose of this study was to investigate the salivary levels of inflammatory and their association with oral health in xerostomía patient
Detailed description
Primary Outcome Measures: * salivary Proinflammatory and anti-inflammatory cytokines * questionnaire is provided to the patient for xerostomia characterization Secondary Outcome Measures: * Probing pocket depth * Probing pocket depth and clinical attachment level * Gingival index * Plaque index * Bleeding on probing
Interventions
DIAGNOSTIC_TESTAnalysis of the saliva
IFN-, IL-10, IL-1b, IL-4 and IL-6
Sponsors
Universidad de Murcia
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
• The patient must have clinical symptoms of xerostomia (dry mouth)
Exclusion criteria
* Head and neck radiotherapy * Administration anti-inflammatory drugs or antibiotic therapies within the previous 6 months * Patients who are unable or unwilling to cooperate * Patient suffering from cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| saliva flow rate | 2 months | Unstimulated salivary flow rate. Pathological \< or 1.5 ml/ 15 minutes. |
| Xerostomia | 2 months | Visual Analogue Scale (VAS) for xerostomia severity (0 cm: no xerostomía , 10cm : very severe xerostomia ). |
| Interleukins | 2 months | Analytes in saliva IFN-(pg/ml), IL-10(pg/ml), IL-1b(pg/ml), IL-4 (pg/ml)and IL-6 (pg/ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oral Exam | 4 months | Caries number, natural teeth number |
| Periodontal evaluation | 4 months | periodontal( gingival index, bleeding index, clinical attachment level, probing depth,number dental implant .A periodontal probe will be inserted between the tooth and the gum in the gingival sulcus and a measurement of the pocket depth will be measured by a trained dentist in all subjects according to American Academy of Periodontology classification of periodontal diagnosis |
Countries
Spain
Outcome results
None listed