Hyperaldosteronism; Primary, Hypertension Secondary
Conditions
Keywords
prevalence, primary aldosteronism, hypertension, nationwide
Brief summary
To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with newly diagnosed hypertension.
Detailed description
This is a nationwide sampling study. To investigate the prevalence of primary aldosteronism (PA) in Chinese patients with hypertension, we will conduct a case detection of PA in Chinese hypertensive patients from 10 centers of China (including Beijing, Chongqing, Shanghai, Guangzhou, et al.); furthermore, a case confirmation of PA (captopril challenge test and saline infusion test) will be performed if the result of case detection is positive. This study will be completed in two years.
Interventions
DIAGNOSTIC_TESTAldosterone/renin ratio (ARR) testing
Plasma aldosterone concentration tests, Direct renin concentration tests
DIAGNOSTIC_TESTConfirmatory tests
Captopril challenge test, Saline infusion test
Sponsors
Fu Wai Hospital, Beijing, China
Qifu Li
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Newly diagnosed hypertension(with a course less than six months); 2. Drug negative, or voluntary to discontinue/change the anti-hypertensive medications; 3. Aged between 18-80 year, gender is not limited; 4. Voluntary to sign on the informed consent.
Exclusion criteria
1. patients with severe cardiac, hepatic or renal dysfunction; 2. suspicious or confirmed other types of secondary hypertension, including Cushing's syndrome, pheochromocytoma and renal artery stenosis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects with newly diagnosed hypertension | 2 years | To calculate the prevalence of PA in Chinese patients with hypertension |
| Number of subjects with confirmed primary aldosteronism (PA) | 2 years | To calculate the prevalence of PA in Chinese patients with hypertension |
| Prevalence of PA | 2 years | Prevalence of PA= Number of PA / Number of subjects with hypertension |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fasting blood glucose | 2 years | Characteristics of PA in Chinese patients with hypertension |
| Age | 2 years | Characteristics of PA in Chinese patients with hypertension |
| Cardiovascular events | 2 years | Characteristics of PA in Chinese patients with hypertension |
| Blood pressure | 2 years | Characteristics of PA in Chinese patients with hypertension |
| Family history of hypertension | 2 years | Characteristics of PA in Chinese patients with hypertension |
Countries
China
Outcome results
None listed