Exercise Training, Lung Transplant
Conditions
Brief summary
The HILT study is a prospective, single-blinded, randomized controlled trial comparing a high-intensity exercise training intervention with usual care among adult lung transplant recipients. Patients randomized to the training intervention arm will undergo individually tailored high-intensity exercise training (80-95% of maximum heart rate) three hours per week for 20 weeks. Training will be conducted at local fitness centers on a one-on-one basis.
Interventions
BEHAVIORALHigh-intensity training
The exercise program will include a cardiovascular warm-up, high intensity interval training and progressive resistance training (PRT). The intervention will focus on high-intensity training, mainly by uphill walking on a treadmill at 80-95 % of the maximal heart rate and PRT in three series at 6-12 RM by leg press, chest press, back extension, seat row, and front raises. During the first four weeks, the patients will be introduced to the program while focusing on safety, techniques and familiarization. The endurance intensity and strength load will then continuously increase based on the patients' improvement, tolerance of dyspnea, and feelings of well-being or fatigue on each exercise day.
Sponsors
Norwegian School of Sport Sciences
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Stable medical condition in the opinion of the enrolling investigator * Able and willing to give informed consent
Exclusion criteria
* Expected survival less than 12 months * Unable to complete a maximal exercise test on a treadmill until exhaustion * Language barrier that interferes with data collection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in peak oxygen uptake | 0-20 weeks | Measured by cardiopulmonary exercise test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in forced expiratory volume in one second (FEV1) | 0-20 weeks | Measured by spirometry |
| Change submaximal exercise capacity | 0-20 weeks | Measured by 6-minute walk distance |
| Change in leg strength | 0-20 weeks | Measured by maximum leg press |
| Change in total body composition (fat, muscle and bone mass) | 0-20 weeks | Measured by dual-energy x-ray absorptiometry (DEXA) |
| Change in hand strength | 0-20 weeks | Measured by grip strength dynamometer |
| Change in health-related quality of life | 0-20 weeks | Measured by Short Form 36 (SF-36) |
| Change in upper body strength | 0-20 weeks | Measured by maximum breast press |
Countries
Norway
Outcome results
None listed