Heart Arrest
Conditions
Keywords
Heart arrest, Hypothermia, EEG, Prognosis
Brief summary
The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.
Interventions
DEVICEAmplitude integrated electroencephalography
Frontal Amplitude-integrated Electroencephalogram in Early Prognostication After Cardiac Arrest
Sponsors
Seoul St. Mary's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age: 19 years and older * underwent TH
Exclusion criteria
* Died within 72 h after cardiac arrest * Spontaneous or traumatic brain injury * Known history of neurological diseases (such as epilepsy)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2 | at day 180 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 uV. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 | — |
| Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 | Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 uV. |
| Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 | Unfavorable aEEG patterns include flat trace (FT), burst-suppression (BS) and status epilepticus (SE). FT is defined as isoelectric activity. BS is defined as the virtual absence of activity (\<2uV) between bursts of high voltage (\>25 uV). SE was defined as repetitive epileptiform discharges with amplitudes \>50 uV and a median frequency 1 Hz for \>30 min. |
| Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 | — |
| Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5 | at day 180 | — |
Countries
South Korea
Contacts
Primary ContactSang Hoon Oh, MD
Outcome results
None listed