The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03153436

Enrollment

Registered

2017-05-15

Start date

2016-08-28

Completion date

2017-04-26

Last updated

2017-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myoinositol, Cryopreservation, Human, Sperm

Brief summary

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Detailed description

Sperm cryopreservation is considered the most valuable and used way to preserve male reproductive function. Unfortunately, osmotic effects of freezing and thawing during the cryopreservation process negatively affect sperm morphology and motility . Myoinositol is the most biologically important form of inositol in nature. In male reproductive system, myoinositol appears to regulate sperm motility, capacitation and acrosomal reaction. The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Interventions

BIOLOGICALMyoinositol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Infertile men with normal or abnormal semen analysis

Exclusion criteria

* Azoospermic samples

Design outcomes

Primary

Measure	Time frame	Description
Cryo-survival rate	7 months	Post-thawing cryo-survival rates of both aliquots ( myo and control) are compared in both groups (A and B).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026