Erythema Chronicum Migrans
Conditions
Brief summary
The purpose of this study is to compare the efficacy of 7-day versus 14-day doxycycline treatment in patients with erythema migrans.
Interventions
DRUGDoxycycline 100 MG Oral Tablet bid, 7 days
Patients will receive doxycycline for 7 days.
DRUGDoxycycline 100 MG Oral Tablet bid, 14 days
Patients will receive doxycycline for 14 days.
No intervention.
Sponsors
University of Ljubljana School of Medicine, Slovenia
University Medical Centre Ljubljana
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* solitary erythema migrans
Exclusion criteria
* pregnancy or lactation * immunocompromised * serious adverse event to doxycycline * taking antibiotic with antiborrelial activity within 10 days * multiple erythema migrans or extracutaneous manifestations of lyme borreliosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Treatment outcome in patients treated for erythema migrans with doxycycline for 7 or 14 days | At 12 months after enrollment. | Objective sequelae and post-treatment subjective new or increased symptoms (NOIS) in patients treated for erythema migrans with doxycycline for 7 or 14 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of nonspecific symptoms in patients with erythema migrans and control subjects | At 12 months after enrollment. | Number of patients after treatment with doxycycline for 7 or 14 days for erythema migrans and number of control subjects (without a history o Lyme borreliosis) with nonspecific symptoms. |
Countries
Slovenia
Outcome results
None listed