Menstrual Migraine
Conditions
Keywords
Migraine, Intracranial pressure, Headache
Brief summary
An increase in intracranial pressure (ICP) during migraine attacks is possible and could contribute to pain initiation and maintenance. From now on, it was not possible to measure ICP in a non-invasive way. The development of a new tool allows non-invasive self-measures of ICP variations. Thus, it is possible for the first time to look for such ICP variations during migraine attacks and to conclude if this mechanism is implied in the pathophysiology of migraine.
Detailed description
Womens presenting with regular menstrual migraine treated with triptans will be included in the study. Self-measure of ICP will be performed outside and during menstrual migraine attacks. The potential variations will be compared to the measures done on matched healthy women outside and during menses.
Interventions
OTHERIntracranial pressure variations
Self-measure of ICP will be performed outside and during menstrual migraine attacks.
Sponsors
University Hospital, Clermont-Ferrand
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 to 50 non menopausal women * Menstrual migraine * Using a triptan as usual treatment to relieve attacks * Usual triptan efficacy although recurrence is possible
Exclusion criteria
* Disease of the ear * Intracranial hypertension * Chronic daily headache * Use of topiramate or acetazolamide * Triptans used more than 10 days/month * Analgesic drug used more than 15 days/month * Uncontrolled high blood pressure * BMI \>30 * Ongoing allergic rhinitis or flu
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intracranial pressure variations | during menstrual migraine attacks | Measured during menstrual migraine attacks compared to ICP in non-migraine days and in matched healthy women |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Relationships between ICP variations and clinical parameters | during menstrual migraine attacks | Age, BMI, pain intensity, pulsating pain, allodynia, nausea, photophobia, phonophobia, dizziness, tinnitus |
| Relationships between ICP variations and pain relief | during menstrual migraine attacks | — |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Backup ContactPierre CLAVELOU
Outcome results
None listed