Ulcerative Colitis
Conditions
Keywords
fungal, mucosa, diversity, Basidiomycete
Brief summary
We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.
Detailed description
In recent years, the relationship of intestinal fungus with inflammatory bowel disease was gradually revealed. We divided the patients with ulcerative colitis into three groups on the basis of World Gastroenterology Organisation (WGO) classification about inflammation degree and progress classification and established the healthy control group. Analyzing the diversity of the fungal and bacterial within colon mucosa between patients with different clinical classification, for example, the proportion of bacteria and fungi, the proportion of candida albicans, the proportion of yeasts, and so on.
Interventions
OTHERulcerative colitis
We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
OTHERControl
We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
Sponsors
Qilu Hospital of Shandong University
Xiuli Zuo
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients at our tertiary care medical center, aged between 18 and 80 years, scheduled to undergo surveillance colonoscopy. * The patients with ulcerative colitis for ulcerative colitis group. * The patients without ulcerative colitis for control group. * 18-80 years.
Exclusion criteria
* Using antibiotics, glucocorticoid and immunosuppressants wintin one month. * There are contraindications for enteroscopy and biopsy. * There are other intestinal diseases. * Pregnancy or breast-feeding women. * Patients with serious lung disease and mental illness.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fungus detection rate | 6 months | Fungi detection rate was defined as the percentage of patients in whose colonic mucosa at least one kind of fungus were identified. |
| yeasts detection rate | 6 months | Yeasts detection rate was defined as the percentage of patients in whose colonic mucosa yeasts were identified. |
| candida albicans detection rate | 6 months | Candida albicans detection rate was defined as the percentage of patients in whose colonic mucosa candida albicans were identified. |
Countries
China
Contacts
Primary ContactXiuli Zuo, PhD
Outcome results
None listed