Improvement of Foodallergy Diagnostic in Gastrointestinal Tract

Improvement of Foodallergy Diagnostic in Gastrointestinal Tract With a New Kind of Sampling

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03151252

Enrollment

Registered

2017-05-12

Start date

2014-10-31

Completion date

2022-12-31

Last updated

2024-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food Allergy

Brief summary

Currently, diagnostic possibilities for the detection of food allergy in the gastrointestinal tract are scarce. The endoscopic segmental Lavage is the method of choice, but it´s controversial. Additional to the endoscopic segmental lavage fluid a cytobrush is used for collecting the mucosa cells and biopsies are taken. Comparative to the Lavage specific IgE antibodies, Tumor necrosis factor- alpha, Eosinophilic cation protein and mastcell tryptase were measured.

Interventions

DIAGNOSTIC_TESTCytobrush

During the endoscopic Investigation the mucosa cells were collected by brushing the colon via cytobrush.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* all patients with suspicion of food intolerance and confirmed food allergy

Exclusion criteria

* pregnant and patients under allergy medication (antihistaminic, cortison)

Design outcomes

Primary

Measure	Time frame
detection of specific IgE Antibodies in colon	1 hour

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026