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Effect of Pregabalin on the Postoperative Analgesia in RFA of Focal Lesions in the Liver

Effect of Preoperative Administration of Oral Pregabalin on the Postoperative Analgesia in Patients Scheduled for Radiofrequency Ablationof Focal Lesions in the Liver

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03151213
Acronym
pregabalin
Enrollment
70
Registered
2017-05-12
Start date
2017-01-01
Completion date
2017-06-30
Last updated
2026-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular Cancer

Brief summary

The study aimed to investigate the preemptive analgesia efficacy of of preemptive pregabalin for the postoperative pain management after radiofrequency ablation (RFA) of liver cancer.

Detailed description

Our data will investigate if preemptive administration of pregabalin will have a role in reducing postoperative pain after radiofrequency ablation (RFA) of liver cancer.

Interventions

DRUGPregabalin 150mg

Pregabalin 150mg before RFA of liver cancer

OTHERPlacebo

Placebo before RFA of liver cancer

Sponsors

Sherief Abd-Elsalam
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)

Masking description

Double blinded by closed envelops

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* HCC patients, Child A, B, scheduled for Radiofrequency ablation of HCC.

Exclusion criteria

* Encephalopathy, Renal impairment

Design outcomes

Primary

MeasureTime frameDescription
visual analogue pain scale (VAS Pain) post operatively2 weeksAmplitude of pain postoperatively

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATORAmr Magdy Abdelfattah, consultant

Tanta University Faculty of Medicine

STUDY_DIRECTORSherief Abd-Elsalam, Consultant

Tanta university Faculty of Medicine

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 14, 2026