Accelerated Vaccination Schedule Against Hepatitis B Virus With Combined Hepatitis A and B Vaccine Among Hemodialysis Patients

Accelerated Vaccination Schedule Against Hepatitis B Virus With Combined Hepatitis A and B Vaccine Among Hemodialysis Patients, Does it Works?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03149874

Enrollment

114

Registered

2017-05-11

Start date

2014-12-01

Completion date

2017-05-01

Last updated

2023-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodialysis Complication, Hepatitis B

Brief summary

The aim of this study is to examine the result of seroprotection using the accelerated vaccination schedule in vaccination of hemodialysis patient through using combined hepatitis A and B vaccine.

Interventions

DRUGHepatitis B recombinant DNA vaccine

Hepatitis B recombinant DNA vaccine

DRUGCombined hepatitis A and B vaccine

Combined hepatitis A and B vaccine given to the patients

Study design

Allocation

RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Patient seuentially randomized to either vaccine

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age was above 18 years * Hemodialysis patient * All patients had undetectable hepatitis B virus surface antigen and antibody

Exclusion criteria

* A positive serum hepatitis B virus surface antigen and antibody * patient received a previous course of hepatitis B virus vaccine

Design outcomes

Primary

Measure	Time frame	Description
Hepatitis B virus Seroprotection after one month	one month after third dose of the vaccine	Hepatitis B virus surface antibodies titer after one month
Hepatitis B virus Seroprotection after three months	three months after third dose of the vaccine	Hepatitis B virus surface antibodies titer after three month

Secondary

Measure	Time frame	Description
Fever	4 Days after each vaccination dose	The proportion of fever among patients in both arms
Pain scale	1 Hour after each vaccination dose	Visual pain scale for pain from injection

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026