Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

Comparison of Effects of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia on Maternal and Fetal Outcomes After Cesarean Section

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03149588

Enrollment

Registered

2017-05-11

Start date

2017-04-03

Completion date

2019-11-30

Last updated

2018-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean Section, Propofol, Sevoflurane

Brief summary

Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly. The aim of this study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia, and to try to determine which anesthetic is better for maternal and fetal outcomes after caesarean section.

Detailed description

General anaesthesia is mostly performed for emergency grade 1 caesarean section and due to a lack of time to apply a neuraxial anaesthesia technique. Rapid sequence induction using propofol and rocuronium should become the standard for general anaesthesia in the obstetric patient. Both sevoflurane and propofol are considered to be appropriate for the maintenance of general anaesthesia during caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly in the past. And for most anaesthesiologists, the clinical experience with general anaesthesia for caesarean section is very low. This study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia.

Interventions

DRUGpropofol

Using propofol and remifentanil as maintenance of general anesthesia during caesarean section.

DRUGsevoflurane

Using sevoflurane and remifentanil as maintenance of general anesthesia during caesarean section.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Inclusion criteria

* ASAⅠor Ⅱ parturients (aged 18-35 years) undergoing elective caesarean section

Exclusion criteria

* Parturients with severe pregnancy complications

Design outcomes

Primary

Measure	Time frame	Description
Maternal hospital stay	Before dismissed from hospital	Maternal hospital stay time
Maternal mortality	Before dismissed from hospital	Maternal mortality in hospital
Newborn hospital stay	Before dismissed from hospital	Newborn hospital stay time
Newborn mortality	Before dismissed from hospital	Newborn mortality in hospital

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026