Coagulation Disorder, Blood, Platelet Function
Conditions
Keywords
Aggregometry
Brief summary
The study aims to investigate the impact of preeclampsia on hemostasis.
Detailed description
In comparison to healthy pregnant women and non-pregnant woman, this study analyses parameters of primary hemostasis and plasmatic coaguation in preeclamptic pregnant woman. Detailed analyses of the platelet function is performed using the Multiple Electrode Aggregometry, detailed analyses of the plasmatic coagulation syste is performed by isolated coaguation factor analyses and conventional coagulation analyses.
Interventions
DIAGNOSTIC_TESTAggregometry, Monitoring of plasmatic hemostasis
Multiple Electrode Aggregometry using the Multiplate system Coagulation factor analyses (FXIII, FVIII, vWF) Parameters of conventional coagulation testing (aPTT, INR, Platelet count)
Sponsors
Goethe University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Inclusion criteria
* Platelet count \> 100 / nll * In study group and control group 1: Week of Pregnancy: 35-40 * in control group 2: healthy, not pregnant woman
Exclusion criteria
* Hereditary coagulopathy * Missing content of the patient / proband * Eclampsia * HELLP syndrome * CRP \> 1 mg/dl * Fever (\> 38°C)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Area under the aggregation curve in the ADPtest of the Multiple Electrode Aggregometry | Between 35th and 40th week of pregnancy; in control group 2 (not pregnant) within 1 week after inclusion into the study | ADP induced platelet aggregation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Area under the aggregation curve in the ASPItest of the Multiple Electrode Aggregometry | Between 35th and 40th week of pregnancy; in control group 2 (not pregnant) within 1 week after inclusion into the study | Arachidonic acid induced platelet aggregation |
| Area under the aggregation curve in the TRAPtest of the Multiple Electrode Aggregometry | Between 35th and 40th week of pregnancy; in control group 2 (not pregnant) within 1 week after inclusion into the study | Thrombin induced platelet aggregation |
| Parameters of plasmatic coagulation system | Between 35th and 40th week of pregnancy; in control group 2 (not pregnant) within 1 week after inclusion into the study | von Willebrand Factor, Factor VIII, Factor XIII, parameter of conventional coagulation testing (apTT, INR, platelet count, Fibrinogen) |
Contacts
Primary ContactChristian F Weber, MD, PhD
Backup ContactNiels Loechelt, MD
Outcome results
None listed