Knee Arthropathy
Conditions
Keywords
MPV, NLR, Postoperative pain
Brief summary
In the planned study the investigators want to evaluate the relation between postoperative complications and minor/ major morbidities, mortality and Mean Platelet Volume (MPV) and Neutrophil/ lymphocyte (N/L) ratio.
Detailed description
* In this study the investigators aim to determine the relation between the MPV and N/L ratio and the incidence of postoperative adverse events and complications in patients undergoing knee arthroplasty. * In this study only the laboratory tests that are routinely used for the operative patients are going to be used and no extra tests will be performed. The study will begin after the postoperative blood samples are collected for routine laboratory measurements. The patients will be allocated to 4 groups according to the type of anesthesia and VAS scores. Preoperative and postoperative peripheral blood total whole blood MPV and N/L ratio and 1st 6th 12th ve 24th hours VAS scores and complications, morbidities and mortality will be recorded. The patients will receive analgesics according to the routine practice in the ward and the doses of analgesics given will be recorded at 1st 6th 12th ve 24the hours wil be recorded. * Statistical analysis: the numerical variables will be analyzed tested with Kolmogorov-Smirnov test for normality. For the parametric variables that are normally distributed t-test will be used for the comparison between groups. For the parametric variables that are not normally distributed Mann Whitney-U test will be used. All the categorical variables will be evaluated with q- square tests. A p value \< 0.05 will be determined as statistically significant.
Interventions
None listed
Sponsors
Akdeniz University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* knee arthroplasty patients with general or spinal anesthesia.
Exclusion criteria
* patients not giving consent * reoperations * patients having inflammatory disease * infection in the knee * sepsis * bleeding disorders * hematologic diseases, * using steroids. * trauma * fracture patients, * bilateral knee prothesis * combined surgery procedures * patients needing perioperative transfusions * uncooperative patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative VAS (visual analogue scale) score | VAS score at postoperative twenty-forth hours will be evaluated | postoperative visual analog scale score for pain evaluation 0,10,20,30,40,50,60,70,80,90,100) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| analgesic drugs | total dose of analgesic drugs required at twenty four hours will be evaluated | analgesic drugs given according to the routine practice in the ward |
| postoperative major morbidities | at postoperative first, sixth, twelfth and twenty-forth hours | postoperative Myocardial Infarction (MI), Acute Kidney Injury(AKI), and Cerebrovascular Events (CVO)s. |
Other
| Measure | Time frame | Description |
|---|---|---|
| postoperative side effects | at postoperative first, sixth, twelfth and twenty-forth hours | nausea, vomiting, abdominal pain, agitation, head ache, muscular weakness, dizziness,hiccups, bronchospasm, bradycardia, itching, urinary retention, |
Countries
Turkey (Türkiye)
Outcome results
None listed