the Use of Antidepressants in Patients With Bipolar Depression
Conditions
Brief summary
The bipolar depression patients of 18-55 years old were recruited. At the time of enrollment, the demographic, symptomatic, neuropsychological, neurobiological and genetic data was collected. After the completion of the baseline assessment and examination, the patients were given lithium carbonate or lithium carbonate combined with SSRI antidepressant treatment. Clinical evaluation was performed at 2 and 8 weeks after treatment, including the therapeutic efficacy and adverse drug reactions, and monitoring of serum lithium concentration. The patients further receive the fMRI scans after treatment for 8 weeks. Through above work, this study aimed to provide some guidance for the use of antidepressants in patients with bipolar depression.
Interventions
DRUGLithium Carbonate
bipolar depression recieve lithium Carbonate treatment
DRUGlithium carbonate combined with SSRI antidepressant treatment
lithium carbonate combined with SSRI antidepressant treatment
Sponsors
Peking University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* age 18-55 years old, bipolar depression
Exclusion criteria
* other mental illness, serious somatic illnesses, MRI contradictions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HRSD reduction ratio | 8 weeks | HRSD reduction ratio |
Countries
China
Contacts
Primary ContactJi-Tao Li, MD
Outcome results
None listed