Acute Lymphoblastic Leukemia, Exercise, Quality of Life
Conditions
Brief summary
* To compare between modified strength training program and aerobic exercises on quality of life on children with Acute Lymphoblastic Leukemia. * To compare between modified strength training program and aerobic exercises on functional capacity on children with Acute Lymphoblastic Leukemia.
Detailed description
This study will be done to determine any exercise from aerobic exercises or modified strength training program will be more effective on quality of life and functional capacity on children with Acute Lymphoblastic Leukemia .Acute Lymphoblastic Leukemia is wide spread in the world and the children with this disease are fragile so must know the most program effect.
Interventions
BEHAVIORALAerobic exercises
Aerobic exercises will do by using treadmill for children of study group A. it will consist of (max.incline15% - max. speed - heart rate grips and wireless chest strap - smooth virtual fitness trainer - smooth drop folding frame - impression shock absorption cushioning system).
BEHAVIORALModified strength training
Dumbbells will be used to conduct the modified strength training program for children of group B. This exercises included five exercises for the main muscle groups: bench press, leg press, seat row, leg extension and lat pull down.
Sponsors
Children's Cancer Hospital Egypt 57357
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Intervention model description
Experimental controlled randomization using Block Stratified Randomized Software program, after obtaining informed consent from illegible patient or his caregiver.
Eligibility
Sex/Gender
ALL
Age
8 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Age range from8-12years. * Children during 3rd phase( maintenance phase of the treatment). According San et al(2007) who found children with Acute Lymphoblastic Leukemia in maintenance phase of treatment can safely perform both aerobic and resistance training . * Time elapsed since the start of the maintenance phase \>20weeks. * Children with muscle weakness due to chemotherapy. * The height , weight and body mass index of the child will take on standard scale. * preserved cardiac structure and function as assisted by echo-cardiogram. * The children have ability to walk.
Exclusion criteria
Children who have one or more of the following criteria will be excluded from the study: * Receiving more intensive chemotherapy. * Mental disabled. * Sever cardiomyopathy (ejection fraction \<40%, ECG will be used as a pretest as it might be a more sensitive tool to exclude angina pectoris). * Low blood platelet levels (\< 50.000 per µl). * Marked anemia (hemoglobin \< 8 g/dl). * Severe cachexia (i.e., weight mass loss \> 35%). * Pain in bone. * Inability to walk. * Sensory disturbance. * Peripheral neuropathy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of quality of life | at week 20 | The pediatric quality of life inventory (PedsQL) is a modular approach to measure health-related quality of life in healthy children and adolescents and those with acute and chronic health conditions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement of functional capacity | at week 20 | 6 minute walk test is a test to measure functional capacity by using pulse oximeter to detect percentage of oxygen saturation at peripheral capillaries. |
Countries
Egypt
Outcome results
None listed