Lower Limb Arteritis, Restenosis
Conditions
Brief summary
The initial hypothesis of this work is that the genesis and the evolution of the atheromatous plaque are partly controlled at the molecular level and in particular by the microRNAs through their role as regulator of the genes. The study of the tissue and serum profile over time of specific microRNAs involved in the regulation of atheromatous plaque correlated with clinical data and restenosis imaging will allow to define biological markers of restenosis in the patient with an arteritis of the lower limbs . This study is a pioneer in the field and it would be imprudent to conclude that a biomarker would be used clinically at the end of this work alone. Nevertheless this study will make a major advance in this topic, in vivo intervention studies with inhibition or over-expression of microRNA will obviously be necessary to confirm the use of these as biomarkers of arteritis of the lower limbs. Regular assay of reliable biomarkers in arterial patients will ultimately suggest early management to best adapt surgical and medical treatment.
Interventions
OTHERTo look for serum microRNA profiles associated with restenosis
To look for serum microRNA profiles associated with restenosis
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any person to be surgically treated for arteritis on the femoropoplitetic stage, * affiliated to a social security scheme, * informed of the study and not opposed to it.
Exclusion criteria
* Any person taken in charge for an arteritis on the femoro-popliteal floor refusing to participate in the study, * or not being able to express its consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study of the tissue and serum profile of microRNAs by quantification by real-time PCR | 3 years |
Countries
France
Outcome results
None listed