Healthy
Conditions
Keywords
oxytocin, sex hormone, verbal reward, mate selection, metaphorical language
Brief summary
The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.
Detailed description
To investigate whether oxytocin (24IU) might interact with female sex hormone in modulating the rewarding effect of compliment to women in a romantic context. The study employs a double-blind, within-subject, placebo-control design. Women will be administered with the same drug twice (oxytocin or placebo) respectively the fertile and luteal phase followed by a MRI scanning. During fMRI participants will rate men's attraction based on their facial pictures of average attractiveness associated with compliments of different combination of form and topic. Each male face will be paired with two sentences of the same kind. After the fMRI participants will recall the judgment followed by a memory test during which they have to indicate whether the they have seen the face during scanning (old) or whether it is an unknown face (new).
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Single in the past 3 months * Healthy subjects with regular menstrual cycle
Exclusion criteria
* Pregnant, menstruating, taking oral contraceptives * metal implanted, with tatoo, or hair dyed within 6 months * participated in another intranasal experiment within 6 months * with a history of past or current psychiatric or neurological disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases | 45min-120min after treatment | Effects of oxytocin versus placebo nasal spray on neural processing of reward will be compared between different cycle phases |
Countries
China