Skip to content

Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle

Does Oxytocin Modulate Rewarding Effect of Metaphorical Compliments Fluctuating With Women's Fertility and Luteal Phase in a Romantic Context

Status
Completed
Phases
Early Phase 1
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03144115
Enrollment
80
Registered
2017-05-08
Start date
2016-10-31
Completion date
2018-07-31
Last updated
2018-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

oxytocin, sex hormone, verbal reward, mate selection, metaphorical language

Brief summary

The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.

Detailed description

To investigate whether oxytocin (24IU) might interact with female sex hormone in modulating the rewarding effect of compliment to women in a romantic context. The study employs a double-blind, within-subject, placebo-control design. Women will be administered with the same drug twice (oxytocin or placebo) respectively the fertile and luteal phase followed by a MRI scanning. During fMRI participants will rate men's attraction based on their facial pictures of average attractiveness associated with compliments of different combination of form and topic. Each male face will be paired with two sentences of the same kind. After the fMRI participants will recall the judgment followed by a memory test during which they have to indicate whether the they have seen the face during scanning (old) or whether it is an unknown face (new).

Interventions

DRUGOxytocin
DRUGPlacebos

Sponsors

University of Electronic Science and Technology of China
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* Single in the past 3 months * Healthy subjects with regular menstrual cycle

Exclusion criteria

* Pregnant, menstruating, taking oral contraceptives * metal implanted, with tatoo, or hair dyed within 6 months * participated in another intranasal experiment within 6 months * with a history of past or current psychiatric or neurological disorder

Design outcomes

Primary

MeasureTime frameDescription
Oxytocin effect on neural activity as assessed via fMRI towards reward between fertility and luteal phases45min-120min after treatmentEffects of oxytocin versus placebo nasal spray on neural processing of reward will be compared between different cycle phases

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 12, 2026