Human Immunodeficiency Virus Infection, Inflammation
Conditions
Brief summary
This is a pilot study of a new 9-session individually delivered cognitive behavioral intervention targeting sexual minority stress. In this study, 40 HIV+ men sexual minority men will be recruited for the study then will be randomly assigned to either the new 9 session intervention or a writing task condition.
Interventions
BEHAVIORALAWARENESS for Sexual Minorities
9 session, individually delivered, cognitive behavioral intervention focused on modifying sexual minority stress responses to reduce the impact of sexual minority stress experiences.
BEHAVIORALWriting tasks
Writing sessions to explore daily activities.
Sponsors
National Institute on Drug Abuse (NIDA)
University of California, San Francisco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Provide evidence or documentation of HIV positive status (e.g. a letter of diagnosis or medication bottles with matched photo ID) * Be English speaking * Be able to consent * Sexual activity with a man in the 3 years prior to initial contact or identification as gay or bisexual * Not currently be enrolled in formal substance abuse treatment * Report at least one occasion of drinking 5 or more drinks or of using an illicit substance in the previous 3 months, but not meet criteria for a severe substance use disorder.
Exclusion criteria
* Presence of a severe substance use disorder * Presence of current symptoms consistent with schizophrenia or bipolar disorder, which would indicate that an intervention targeting these symptoms would be more appropriate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Gene expression | Baseline, ~9 weeks (at conclusion of intervention), 4 month follow-up | Gene expression related to inflammation measured in blood |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Substance Use | Baseline, ~9 weeks (at conclusion of intervention), 4 month follow-up | Substance Use measured through Alcohol Smoking and Substance Involvement Screening Test (ASSIST) |
Countries
United States
Outcome results
None listed