Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid

Efficacy of Dentifrices Containing Arginine Versus Fluoride on Microbial Acid Using Chair Side(Potential of Hydrogen) pH Meter Assessment Method in Adult Population: Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03143023

Enrollment

Registered

2017-05-08

Start date

2017-06-30

Completion date

2018-02-28

Last updated

2017-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Brief summary

This study will be conducted to evaluate the effect of arginine versus fluoride containing toothpaste on neutralization of microbial acid produced by Cariogenic bacteria in adult population using chair side assessment method.

Detailed description

.28 volunteer participants will be assigned in this study. Participants will be randomly divided into two groups(n=14) according to type of toothpaste D where groups D1 patient will use arginine containing toothpaste while groups D2 the patient will used the fluoride toothpaste with a number of 14 patients in each group. The pH will be evaluated according to time in relation to the brushing with toothpaste (T) where (T0) represent salivary pH before brushing with toothpaste , (T1) represent salivary pH 10 minutes after brushing with toothpaste at fixed time of the day.

Interventions

DRUGarginine toothpaste

acid neutralizer toothpaste

DRUGfluoride toothpaste

bactericidal toothpaste

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Participants should be over 18 years of age. * Systematically healthy. * Not taking any medication interfering with saliva secretion. * Participants who signed informed consent.

Exclusion criteria

* Participants with a compromised medical history. * Participants under systemic disease treatment, with antibiotic, steroid or any medication known to cause dry mouth. * Severe or active periodontal disease. * History of allergies or other adverse reactions to arginine, or oral care product or their ingredient.

Design outcomes

Primary

Measure	Time frame	Description
salivary pH	10 minutes after intervention and control	Salivary pH will be determined by use of a digital pH meter .All salivary pH values will be taken immediately following salivary collection at chairside. The salivary pH values measured before usage of toothpaste termed resting pH, while the salivary pH values measured after usage of toothpaste termed terminal pH.

Contacts

Primary Contactlaura yehia zanati, master

laura_lola92@yahoo.com01204470007

Backup Contactaya mohamed adly, master

adly_sweetdentist@hotmail.com012215228843

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026