Aggressive Periodontitis, Generalized
Conditions
Keywords
clarithromycin, photodynamic therapy, Antimicrobial therapy, Periodontal pocket
Brief summary
To assess the local effect of the antimicrobial therapy using clarithromycin association with photodynamic therapy (PDT) in the treatment of generalized aggressive periodontitis (GAgP).
Detailed description
The aim of the present study was to evaluate the local effect of the antimicrobial therapy using clarithromycin (CLM) association with photodynamic therapy (PDT) in the treatment of generalized aggressive periodontitis (GAgP). Sixty periodontal pockets were select and randomly assigned into four groups: Periodontal Debridement (PD) (n=15): periodontal pockets that received periodontal debridement (PD) with placebo; PD+CLM (n=15): periodontal pockets that received periodontal debridement associated with clarithromycin; PD+PDT (n=15): periodontal pockets that received periodontal debridement associated with photodynamic therapy; PD+CLM+PDT (n=15): periodontal pockets that received periodontal debridement associated with clarithromycin and photodynamic therapy. Probing depth (PD),gain in clinical attachment level (CAL) and bleeding on probing (BOP) were evaluated at baseline, 3 and 6 months post- operatively.
Interventions
Sponsors
Universidade Estadual Paulista Júlio de Mesquita Filho
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosis of GagP * presence of ≥20 teeth * \<35 years of age * periodontal pockets with probing depth (PD) and Clinical Attachment Level (CAL) ≥ 5mm with concomitant bleeding on probing (BOP) in single-rooted teeth from different quadrants - agree to participate in the study and sign a written consent.
Exclusion criteria
* pregnant or lactating * suffering from any other systemic disease (e.g. cardiovascular, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease * received antimicrobials in the previous 6 months * taking long-term anti-inflammatory drugs * received a course of periodontal treatment within the last 12 months * smoked
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical attachment level | 6 months | distance from bottom of pocket to the cement-enamel junction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Probing depth | 6 months | distance from the bottom of sulcus/pocket to gingival margin |
Outcome results
None listed