Hepatic Steatosis, Liver Biopsy, MRI, Quantification
Conditions
Keywords
hepatic steatosis, MRImaging
Brief summary
Evaluation of 4 MRI methods (PDFF 3, 6 and 11 gradient echoes and Spectroscopy) compared to the reference method (liver biopsy) in quantification of hepatic steatosis
Detailed description
Hepatic steatosis is an increasingly frequent pathology, which can lead to severe complications (Cirrhosis, Hepatocellular Carcinoma). The poor quantification of steatosis by ultrasound or scanning and the invasiveness of the reference method (liver biopsy) make MRI a measurement tool of choice. Recent techniques such as proton density measurement with several echoes or spectroscopy are increasingly used for the measurement of steatosis. At the time of the development of therapeutics to reduce fatty liver disease, the use of MRI seems an interesting alternative for longitudinal follow-up in these patients. Our study aims to ensure the reliability of these different MRI techniques for accurate quantification of liver steatosis and to compare them. * Measurement and influence of hepatic fibrosis * Measurement and influence of intrahepatic iron * Influence of intercurrent liver disease * Comparison of the fat measurement of the different hepatic segments * Reproducibility by measurement of inter-observer concordance
Interventions
PROCEDUREQuantification of hepatic steatosis
Quantification of hepatic steatosis (histology, and in MRI)
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing hepatic biopsy (trans-parietal or trans-jugular) in the context of liver disease * signature of written consent
Exclusion criteria
* Contra-indications to MRI * Refusal of protocol * underage patients and protected adults
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation coefficient - for each quantitative MRI variable studied - with the histological score of hepatic steatosis. | at day 1 | Correlation coefficient - for each quantitative MRI variable studied - with the histological score of hepatic steatosis. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of intrahepatic iron | at day 1 | — |
| Measurement of intrahepatic fibrosis | at day 1 | — |
| Measurement of fat in different hepatic segments | at day 1 | (MRI ) |
| Concordance between observers | at day 1 | (for MRI measurements) |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed