Effect of CV4 and Rib Raising Techniques on Autonomic Balance

Variations of Heart Rate Variability and Skin Conductance Reveal the Influence of CV4 and Rib Raising Osteopathic Techniques on the Autonomic Nervous System: a Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03142373

Enrollment

Registered

2017-05-05

Start date

2010-06-30

Completion date

2011-01-31

Last updated

2019-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autonomic Nervous System Disease, Osteopathy

Keywords

heart rate variability, autonomic nervous system, osteopathic manipulative treatment, skin conductance

Brief summary

Background. Heart rate variability (HRV) and skin conductance (SC) highlight autonomic activity and the balance of autonomic nervous system (ANS) which regulates involuntary physiological functions. The modulation of ANS tonic activity is a target of osteopathic manipulative treatment (OMT). The main aim of the present study was to verify whether CV4 and RR osteopathic techniques influence ANS activity. Trial design. A randomized-controlled clinical trial was performed from June 2010 to January 2011. Methods. 32 healthy adults were selected. At enrollment, all healthy subjects were randomized in three groups: CV4 group (CV4 technique), Rib Raising group (RR technique), and Placebo group (PL technique). HRV and SC was recorded during the session respectively with heart rate monitor Polar S810i and with Onda Scanner Domiana (OSD-Microsale model). All data analysis was performed using SPSS statistical software and the significance level set at p≤0.05.

Interventions

OTHERCV4 technique

OTHERRR technique

OTHERPlacebo treatment

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects * between 18-65 years old * both gender

Exclusion criteria

* BMI ≥ 30 * pregnancy * menstrual flow during the session * chronic pain * chronic drug treatment * presence of skin, cardiovascular, psychiatric and neurological diseases * medical history of surgical interventions * OMT in the previous 3 months

Design outcomes

Primary

Measure	Time frame	Description
Heart Rate Variability	1200 seconds	HRV was measured using a heart rate monitor Polar S810i frequency meter

Secondary

Measure	Time frame	Description
Skin Conductance	1200 seconds	SC was measured using a Onda Scanner Domiana (OSD-Microsale model).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026