Deep Vein Thrombosis, Myopathy, Myotonic Dystrophy 1, Pulmonary Embolism, Venous Thromboembolism
Conditions
Brief summary
The risk for venous thromboembolism (VTE) in DM1 and in other inherited myopathies, which can lead to chronic immobilization, are unknown. The purpose of this study is to evaluate incidence of VTE in cohort of patients presenting with DM1 with a comparison to a group of other inheritable myopathies and to a community-based population.
Detailed description
A cohort of more that 2,800 adult patients admitted to our Institutions between January 2000 and November 2014 with genetically proven myopathy will be retrospectively included. Any information relative to their demographic and genetic characteristics, their muscular functional status and the occurrence of VTE will be collected. Statistical analysis will be performed to estimate the incidence of venous thromboembolism in this population, to identify predictors of VTE, and to compare its incidence to a community-based population.
Interventions
None listed
Sponsors
Institut de Myologie, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years * Genetically proven myopathy * Admission in our institutions from January 2000 to November 2014
Exclusion criteria
* Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Any episode of pulmonary embolism and/or deep vein thrombosis, diagnosed according to 2011 AHA guidelines on venous thromboembolism management | 14 years |
Outcome results
None listed