Comparison of IV Fluid Loading and Ondansetron in Reduction of PONV After LC

Comparison of Preoperative Intravenous Fluid Loading and Ondansetron in Reduction of Incidence Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03141645

Enrollment

171

Registered

2017-05-05

Start date

2017-06-20

Completion date

2019-04-01

Last updated

2019-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea, Postoperative Vomiting, Postoperative Nausea and Vomiting

Brief summary

This study is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron (group O) and receiving neither fluid nor ondansetron or control group (group C).

Detailed description

This study is a prospective randomized control trial. It is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron (group O) and receiving neither fluid nor ondansetron or control group (group C). This study is hypothesized that the incidence of PONV in patients receiving preoperative intravenous fluid loading (group F) and patients receiving ondansetron (group O) will be similarly reduced from the control group (receiving neither fluid nor ondansetron).

Interventions

OTHERFluid loading

Patients in the preoperative intravenous fluid loading group (group F) will receive ringer lactate solution 10ml/kg in 15 minutes before starting operation.

DRUGOndansetron

Patients in the ondansetron group (group O) will receive an 8 mg of intravenous ondansetron in 15 minutes before finishing operation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* patients with aged 18 to 70 years with an ASA physical status 1-3

Exclusion criteria

including patients * with pregnant or breast-feeding patients * having history of taking antiemetic drugs within 24 hours before surgery * with hypersensitivity or allergy to ondansetron * with CKD stage 4, 5 * with congestive heart failure, LVEF \<40 * with cirrhosis child c * refusal or cannot communicate or understand the purpose of this study

Design outcomes

Primary

Measure	Time frame	Description
The incidence of postoperative nausea and vomiting	24 hours	The incidence of postoperative nausea and vomiting within postoperative 24 hours

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026