Surgical Site Infection
Conditions
Brief summary
Surgical site infection (SSI) is a serious operative complication that may be associated with any surgical procedures. It increases morbidity and mortality after cardiac surgery. Plasma concentration of prophylactic antibiotic, routinely cefazolin, is altered by effects of cardiopulmonary bypass. This study is conducted to measure the plasma concentrations of cefazolin to determine its adequacy in pediatric patients undergoing elective cardiac surgery with cardiopulmonary bypass including its correlation with the incidence of postoperative SSI.
Interventions
None listed
Sponsors
Mahidol University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 7 Years
Healthy volunteers
No
Inclusion criteria
1. age \< 7 years old 2. undergoing elective cardiac surgery with cardiopulmonary bypass 3. receive cefazolin as prophylactic antibiotic
Exclusion criteria
1. Known or family history of penicillin or cephalosporins allergy 2. Coexisting liver or renal disease 3. Previous infection or received any antibiotics within 4 weeks 4. Previous surgery with median sternotomy 5. Predicted cardiopulmonary bypass time of less than 30 minutes or more than 150 minutes 6. Severe hemodynamic instability during the operation, requiring mechanical circulatory support
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| plasma concentration of cefazolin in pediatric cardiopulmonary bypass | 12 hours | plasma concentration of cefazolin |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of surgical site infection after elective pediatric cardiac surgery | 30 days | surgical site infection |
Countries
Thailand
Outcome results
None listed