Colorectal Cancer, Liver Metastases
Conditions
Keywords
Liver function, Future liver remnant, Chemotherapy
Brief summary
In liver surgery peroperative assessment och the future liver remnant (FLR) is pivotal in order to avoid posthepatectomy liver failure. To date this is mainly performed by measuring the volume of the FLR. Of course FLR volume acts as a surrogate measure of FLR function and the correlation between volume and function is not always accurate. Several techniques to assess FLR function has been proposed. Hepatobiliary scintigraphy (HBS) and Dynamic MRI are the two such methods. In this study we compare HBS and MRI, in addition to contrast-enhanced CT and ICG, repeatedly performed before and after right hepatectomy in patients with colorectal liver metastases treated with neoadjuvant chemotherapy.
Interventions
DIAGNOSTIC_TESTMultimodal liver function assessment
HBS, MRI, CE-CT and ICG
Sponsors
Karolinska University Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* CRLM treated with neoadjuvant chemotherapy subjected to right hepatectomy
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between HBS and MRI in assessment of FLR function preop | Preop | HBS, MRI, CT and ICG performed the day before surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between HBS and MRI in assessment of FLR function POD 7 | POD 7 | HBS, MRI, CT and ICG performed 7 days after surgery |
| Correlation between HBS and MRI in assessment of FLR function POD 28 | POD 28 | HBS, MRI, CT and ICG performed 28 days after surgery |
Countries
Sweden
Outcome results
None listed