Antibiotic Selection Pressure
Conditions
Brief summary
Stool samples will be collected from two groups of neutropenic patients in the case that a therapy with either meropenem or piperacillin/tazobactam is needed due to a suspected infection. The intestinal resistome will be determined and quantified using shotgun metagenomics. Based on this, regression models will be used to determine the actual selection pressure caused by these drugs, and both selective forces will be compared. The results will reveal if there is a drug that causes a lower selection pressure compared to the other. The study aims to generate knowledge that is required to design effective antibiotic stewardship programs.
Interventions
DRUGmeropenem
Antibiotics to treat infections.
Sponsors
University Hospital of Cologne
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with hemato-oncological disease in neutropenia or with expected neutropenia * Need for treatment with meropenem or piperacillin-tazobactam
Exclusion criteria
* pregnancy * HIV, HBV, HCV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Antibiotic Selection Pressure | under treatment, max. 10 days | Degree of the change of the intestinal resistome. |
Countries
Germany
Outcome results
None listed