Sarcoidosis, Pulmonary
Conditions
Keywords
thoracic sarcoidosis, ultra-low dose computed tomography, Magnetic resonance imaging using Ultrashort echo time
Brief summary
The goal of this study is to evaluate the diagnostic agreement between, on the one hand, ultra-low dose CT and MRI with UTE pulse sequences, and on the other hand, standard CT scan, to quantify lung parenchyma patterns in thoracic sarcoidosis.
Detailed description
Sarcoidosis is a chronic disease involving lung and mediastinum in more than 90% of cases. Five to 25% of thoracic sarcoidosis are complicated by a severe fibrotic lung disease. Computed tomography (CT) is critical for the diagnosis of thoracic sarcoidosis as well as for therapeutic management. Repeated CT examinations, sometimes all life long, raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Based upon tube voltage and current reduction as well as iterative recontsruction, ultra-low dose CT (ULD CT) allows to lower the dose up to that of a traditional chest X-ray. Magnetic resonance imaging (MRI) using Ultrashort echo time (UTE) enables lung parenchyma imaging with high signal-to-noise and spatial resolution.
Interventions
OTHERPatients with thoracic sarcoidosis
Ultra-low dose CT scan and MRI with UTE
Sponsors
Rennes University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 years or more * Diagnosed with thoracic sarcoidosis according to ATS/ERS/WASOG 1999 criteria, with stages 2, 3 or 4, or lung function significantly impaired * For whom a chest CT examination without contrast medium is indicated in the normal follow-up of the disease * covered by social security * having received information about the study and having given written informed consent
Exclusion criteria
* Pregnant woman * Adult person unable to give consent * Patient in exclusion period du to another protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of fibrosis within the 2 lungs (reticulations with or without honeycombing) in standard CT and ULD CT to study diagnostic agreement between these techniques | Day 0 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of consolidation within the 2 lungs in standard CT and ULD CT | Day 0 | — |
| Percentage of pulmonary nodules within the 2 lungs in standard CT and ULD CT | Day 0 | — |
| Percentage of fibrosis within the 2 lungs in standard CT and UTE MRI | Day 0 | — |
| Percentage of ground-glass opacity within the 2 lungs in standard CT and UTE MRI | Day 0 | — |
| Percentage of consolidation within the 2 lungs in standard CT and UTE MRI | Day 0 | — |
| Percentage of pulmonary nodules within the 2 lungs in standard CT and UTE MRI | Day 0 | — |
| Main pulmonary artery to ascending aorta diameter ratio measured with standard CT | Day 0 | — |
| Main pulmonary artery to ascending aorta diameter ratio measured with ULD CT | Day 0 | — |
| Main pulmonary artery to ascending aorta diameter ratio measured with UTE MRI | Day 0 | — |
| Drent score adapted from Oberstein with standard CT | Day 0 | — |
| Drent score adapted from Oberstein with ULD CT | Day 0 | — |
| Percentage of ground-glass opacity within the 2 lungs in standard CT and ULD CT | Day 0 | — |
| Percentage of fibrosis measured by 2 readers for standard CT | Day 0 | — |
| Percentage of fibrosis measured by 2 readers for ULD CT | Day 0 | — |
| Percentage of fibrosis measured by 2 readers for UTE MRI | Day 0 | — |
| Image quality of lung parenchyma assessed quantitatively using standard CT | Day 0 | signal-to-noise and contrast-to-noise ratios |
| Image quality of lung parenchyma assessed quantitatively using ULD CT | Day 0 | signal-to-noise and contrast-to-noise ratios |
| Image quality of lung parenchyma assessed quantitatively using UTE MRI | Day 0 | signal-to-noise and contrast-to-noise ratios |
| Image quality of lung parenchyma assessed qualitatively using standard CT | Day 0 | 4-level scale |
| Image quality of lung parenchyma assessed qualitatively using ULD CT | Day 0 | 4-level scale |
| Image quality of lung parenchyma assessed qualitatively using UTE MRI | Day 0 | 4-level scale |
| Score of tolerance for CT examinations | Day 0 | — |
| Score of tolerance for MRI examinations | Day 0 | — |
| Drent score adapted from Oberstein with UTE MRI | Day 0 | — |
Countries
France
Outcome results
None listed