Comparison Between Surgical Access and Repeated Applications of APDT

Comparison Between Surgical Access and Repeated Applications of APDT to Residual Pockets Treatment in Generalized Aggressive Periodontitis: Randomized Clinical Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03140059

Enrollment

Registered

2017-05-04

Start date

2016-06-30

Completion date

2018-03-31

Last updated

2017-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggressive Periodontitis, Generalized

Keywords

surgical procedure, residual pockets, agressive periodontitis, antimicrobial photodynamic therapy

Brief summary

The aim of this study will be to compare the approach of repeated applications of APDT versus surgical therapy for the treatment of residual pockets in generalized agressive periodontitis.

Detailed description

Scaling and root planing may be insufficient to resolve the periodontal infection resulting in residual periodontal pockets. A method of treatment to these sites would be the surgical therapy, because it allows access to root surfaces, making possible a better decontamination. However, the surgical approach may bring some negative points, as more discomfort and postoperative morbidity, increased transoperatory risk and increased risk of contamination. Thus, finding other alternatives to residual pockets treatment, antimicrobial photodynamic therapy (aPDT) was recently proposed. Therefore, the aim of this study will be to compare the approach of repeated applications of APDT versus surgical therapy for the treatment of residual pockets in generalized agressive periodontitis.

Interventions

PROCEDUREOpen flap debridement

Open flap debridement will be performed to decontaminate root surface

PROCEDURERepeated application of aPDT

Repeated application of photodynamic therapy (aPDT) at 0, 1, 2, 7 and 14 days post-operatively.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of generalized aggressive periodontitis (Armitage, 1999; American Academy of Periodontology, 2015); * Have undergone a first approach for periodontal treatment (full-mouth ultrasonic debridement); * Present at least one residual pocket of probing depth ≥ 5 mm and bleeding on probe not located in furcation region; * Good general health; * Agree to participate in the study and sign the informed consent form (TCLE) after explaining the risks and benefits;

Exclusion criteria

* Systemic problems (cardiovascular alterations, blood dyscrasias, immunodeficiency - ASA III / IV / V) that contraindicate the periodontal procedure; * Have used antibiotics and anti-inflammatories in the last six months; * Smoke ≥ 10 cigarettes/day; * Pregnant or lactating; * Chronic use of medications that may alter the response of periodontal tissues; * Indication of antibiotic prophylaxis for dental procedures;

Design outcomes

Primary

Measure	Time frame
Clinical attachment level	6 months

Secondary

Measure	Time frame
Probing depth	6 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026