Type 1 Diabetes
Conditions
Keywords
Type 1 diabetes, Control, Physical activity, Substrate utilization, Hormonal regulation
Brief summary
The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.
Detailed description
The type 1 diabetes is a common chronic disease characterised by the stop of production of insulin by the pancreas. A lot of factors modify blood glucose. The objective is to study the effect of type 1 diabetes on the use of energy substrates (fats and carbohydrates) during exercise of increasing intensity by a comparison with non-diabetic controls children.
Interventions
PROCEDUREcontrolled physical activity
Comparison between infants with type 1 diabetes and infants without type 1 diabetes during exercise :
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Masking description
no masking is used. All involved know the identity of the intervention assignment
Eligibility
Sex/Gender
ALL
Age
6 Years to 12 Years
Healthy volunteers
Yes
Inclusion criteria
* Children between 6 and 12 years * Tanner stage \<T2 * Type 1 diabetes for more than 1 year for infants with type 1 diabetes
Exclusion criteria
* Tanner stage \> ou = T2 * Obesity * Hormonal disease * Disease who prevent doing exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of substrate utilization between infants with type 1 diabetes and infants without type 1 diabetes during exercise | at day 1 | Measurements will be carried out by indirect calorimetry and the relationship between CO2 et O2 (Metamax) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hormonal regulation of blood glucose | at day 1 | insulin, glucagon, adrenaline, cortisol and growth hormone will be metered according to their half life until 2 hours after physical activity (T12, T20, T40, T60, T120) |
| lipoxmax : the intensity for wich lipid oxydation is maximum will be carried out by indirect calorimetry | at day 1 | during exercise |
| Comparison between infants during 10 days before and 4 days after exercise of blood glucose modification | 10 days before and 4 days after exercise of blood glucose modification | Comparison of curves of interstitial blood glucose measured with Freestyle® |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed