Abdominal Aortic Aneurysm
Conditions
Keywords
Abdominal Aortic Aneurysm, 4D flow MRI, DCE-MRI, T1 and T2 mapping
Brief summary
This study aims to determine whether advanced MRI sequences can provide robust and clinically relevant information about abdominal aortic aneurysms (AAAs). The MRI sequences will study outcomes related to blood flow inside AAA, microvasculature of the AAA vessel wall and intraluminal thrombus inside AAA. Robustness of these MRI sequences will be determined with testing of feasibility and reproducibility. Clinical relevance will be assessed by studying the association between the primary outcomes and disease severity. Disease severity will be expressed by AAA diameter. It is our hypothesis that these parameters are significantly related to disease severity and may therefore be future markers of disease progression.
Detailed description
This prospective study evaluates the feasibility, reproducibility and clinical relevance of MRI sequences in adults with an abdominal aortic aneurysm (AAA). The MRI sequences and their primary outcomes are: * Four-dimensional (4D) flow MRI and wall shear stress (WSS) * Dynamic Contrast-Enhanced (DCE) MRI and kinetic transport constant (Ktrans) * T1 and T2 mapping (T1 and T2 relaxation times) Feasibility is tested by the production of high-quality images that enable calculation of the primary outcomes. Reproducibility is tested by calculating interscan, intra- and interobserver variability. Clinical relevance is tested by assessing the association between primary outcomes and disease severity which is expressed by AAA diameter
Interventions
None listed
Sponsors
Ron Balm
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (≥ 18 years of age) * Abdominal aortic aneurysm with a maximal aneurysm diameter of at least 30 mm
Exclusion criteria
* Contra-indications for MRI * Severely reduced renal function (eGFR \< 30) * Previous allergic reaction to intravenous contrast agents * Suprarenal AAA * Pararenal AAA * Previous aneurysm repair * Inflammatory aneurysm * Mycotic or other infectious aneurysm * Vasculitis * Connective tissue disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Wall shear stress (WSS) | Time of MRI scan | Primary outcome of 4D flow MRI |
| Kinetic transport constant (Ktrans) | Time of MRI scan | Primary outcome of DCE-MRI |
| T1 relaxation time | Time of MRI scan | Primary outcome of T1 mapping |
| T2 relaxation time | Time of MRI scan | Primary outcome of T2 mapping |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wash-in slope | Time of MRI scan | Secondary outcome of DCE-MRI |
| Peak flow velocity inside the aneurysm | Time of MRI scan | Secondary outcome of 4D flow MRI |
| Location of peak wall shear stress | Time of MRI scan | Secondary outcome of 4D flow MRI |
| Time to peak (TTP) | Time of MRI scan | Secondary outcome of DCE-MRI |
| Flow patterns | Time of MRI scan | Secondary outcome of 4D flow MRI |
| Oscillatory shear index | Time of MRI scan | Secondary outcome of 4D flow MRI |
| Reverse reflux rate constant (kep) | Time of MRI scan | Secondary outcome of DCE-MRI |
| Flow velocity at aneurysm entrance | Time of MRI scan | Secondary outcome of 4D flow MRI |
| Mean transit time (MTT) | Time of MRI scan | Secondary outcome of DCE-MRI |
| Area under the curve of contrast uptake | Time of MRI scan | Secondary outcome of DCE-MRI |
| Peak enhancement ratio | Time of MRI scan | Secondary outcome of DCE-MRI |
Countries
Netherlands
Outcome results
None listed