Aged, Exercise, Preoperative Care, Sarcopenia
Conditions
Brief summary
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old). Participants will undergo a wide range of physical fitness measures followed by a four week exercise protocol. Determination of improvement will be by repeated testing of the physical measures taken for baseline. The primary outcome measure will be anaerobic threshold. There will also be a subgroup of participants who will undergo muscle biopsy and D2O ingestion to allow an insight into the mechanistic basis behind exercise training response in this age group.
Interventions
BEHAVIORALHIIT Device: ergometer
Supervised exercise training.
Sponsors
University of Nottingham
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Aged over 70 years. * Sufficient mobility to be able to exercise on a static exercise bike. * Availability for the entire trial period. * Sufficient capacity to consent for the trial.
Exclusion criteria
* Participants under the age of 70 years. Participants with a significant past medical history of: * Myocardial infarction (within last 6 months) * Unstable Angina * Heart failure (NYHA class III/IV) * Uncontrolled Hypertension (BP\>160/100) * Previous stroke/TIA * Severe respiratory disease inc. known pulmonary hypertension(\>25 mmHg), Forced -Expiratory Volume in 1 second \<1.5l. * Brittle asthma / exercise induced asthma * Known cerebral aneurysm or abdominal aortic aneurysm. * Cognitive impairment, which may reduce individuals' ability to provide informed consent. * Inclusion in a recent study which included any form of exercise, taking a drug or ionising radiation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean anaerobic threshold improvement following 4 week HIT protocol. | 4 weeks | Measured via cardiopulmonary exercise testing (mls/kg/min and absolute value L/kg). Pre-Post testing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility | 4 Weeks | Determination of frail elderly patient adherence to HIT programme (number of scheduled sessions successfully completed within 28 days). |
| Mean VO2 peak improvement following 4 week HIT protocol. | 4 weeks | Measured via cardiopulmonary exercise testing (mls/kg/min and absolute value L/kg). Pre-Post testing. |
| Muscle protein synthesis | 4 weeks | Assessment of D2O evaluated muscle protein synthesis following HIT programme. Using mass spectrometry for analysis of stable isotope uptake during training program (arbitrary units). |
| Muscle architecture | 4 weeks | Ultrasound scans used to assess changes in lean muscle mass and architecture following a HIT programme (mm and % pennation angle change). |
| Quality of life improvement | 4 weeks | Quality of life questionnaires to measure subjective outcomes (EQ-5D questionnaire) |
| Daily Activity Level | 4 weeks | Activity questionnaire to quantify habitual physical activity (IPAQ questionnaire) |
| Physical Activity Score | 4 weeks | Subjective assessment of physical ability (DASI questionnaire) |
| Body composition | 4 weeks | DXA changes in body composition (lean muscle mass (%), fat mass (%) and bone density g/cm3)) following a HIT programme |
Countries
United Kingdom
Outcome results
None listed