Coagulation Profile of Patients Undergoing CRS(Cytoreductive Surgery) and Hyperthermic Intraperitoneal Chemotherapy

To Study the Changes in Coagulation Profile in Patients Undergoing CRS(CYTOREDUCTIVE SURGERY) and HIPEC(HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03137745

Enrollment

Registered

2017-05-03

Start date

2015-03-31

Completion date

2016-03-31

Last updated

2017-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Haematological Abnormality

Keywords

Thromboelastography, chemotherapy,hyperthermic

Brief summary

To study the changes in coagulation profile in patients undergoing cytoreductive surgery and Hyperthermic intraperitoneal chemotherapy. The objective of the study is to determine the utility of thromboelastography in comparison to standard coagulation tests in assessing the coagulopathy in patients undergoing CRS with HIPEC.

Detailed description

This is a prospective observational study conducted in 60 patients undergoing CRS with HIPEC in RGCIRC from march 2015- march2016 after taking permission from the institutional review board and informed written consent from the patients. Arterial blood samples were collected before and after HIPEC and on first and second postoperative day for PT,APTT INR,TEG and ABG. Statistical analysis was done using chi square test and unpaired t- test for categorical and continuous variables. Pearson's correlation coefficient was calculated for analysing the correlation between the variables .P - value \<0.05 was considered statistically significant.

Interventions

OTHERthromboelastography

thromboelastography was done pre HIPEC ,post HIPEC and first and second postoperative days

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* ASA 1&2 * Undergoing CRS with HIPEC

Exclusion criteria

* extremities of age * patients with coagulopathy * patients on anticoagulant preoperatively sever organ dysfunctions

Design outcomes

Primary

Measure	Time frame	Description
comparison of thromboelastograph values with standard coagulation tests	1.5 hours after HIPEC	arterial samples were taken for thromboelastography and prothrombin time(seconds), fibrinogen( mg) and patial thromboplastin time( seconds)

Secondary

Measure	Time frame	Description
comparison of various thromboelastograph values with standard coagulation tests	24hours and 48 hours after HIPEC	arterial samples were taken for thromboelastography and prothrombin time(seconds), fibrinogen( mg) and partial thromboplastin time(seconds)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026