Cirrhosis
Conditions
Brief summary
Hospitalized cirrhotic patients are at high risk of complications and adverse outcomes. This study aims to determine the current practice and outcomes in these following areas: 1. Community-acquired infections 2. Nosocomial infections 3. Development of second infections 4. Factors predicting ICU care, organ failure, death, and disability 5. Patterns and adequacy of albumin use in infected and non-infected patients 6. Per and post-liver transplant outcomes 7. Quality-assurance and adequacy of management of complications of cirrhosis such as hepatic encephalopathy, variceal bleeding, hyponatremia, and hypernatremia 8. Regional variations in outcomes and therapeutic strategies
Interventions
None listed
Sponsors
Baylor Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Male and Female over 18 years of age * Cirrhosis as diagnosed by either liver histology or a combination of clinical biochemical (low platelets, elevated bilirubin, and/or INR, low albumin) radiologic (nodular liver on ultrasound) and endoscopic (esophageal varices) criteria * Subject must be able to understand and provide informed consent * Evaluated in the ER or admitted to the hospital for non-elective reasons
Exclusion criteria
* admitted for elective purpose
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequency, Cause, and Outcome of Nosocomial infections | From admission to 1 year post-discharge from the hospital | Collecting details of infections including type, organism, antibiotic used, length of stay, ICU stay and outcomes |
| Frequency, Cause and Outcome of Community-acquired infections | From admission to 1 year post-discharge from the hospital | Collecting details of infections including type, organism, antibiotic used, length of stay, ICU stay and outcomes |
| Factors predicting ICU care, organ failure, death, and disability | From admission to 1 year post-discharge from the hospital | Admission to the ICU and events/outcomes of that subject's admission |
| Development of second infections | From admission to 1 year post-discharge from the hospital | Distinctly different from primary infection |
| Patterns and adequacy of albumin use in infected and non-infected patients | From admission to 1 year post-discharge from the hospital | IV albumin administration |
| Quality-assurance and adequacy of management of complications of cirrhosis such as hepatic encephalopathy, variceal bleeding, hyponatremia, and hypernatremia | From admission to 1 year post-discharge from the hospital | Blood test and other obvious clinical evidence of decompensation |
| Peri and post-liver transplant outcomes based on physiological parameters | From admission to 1 year post-discharge from the hospital | Collection of liver transplant donor and recipient information such as blood group, CMV status, post-transplant infections, immunosuppression regimen, and prophylaxis given. |
| Regional variations in outcomes and therapeutic strategies | From admission to 1 year post-discharge from the hospital | Comparison of data between sites conducting this study across the United States and Canada |
Outcome results
None listed