Characterization of Mechanical Tissue Properties in Patients With Pancreatic, Liver, or Colon Cancer

Characterization of Mechanical Tissue Properties in Pancreas, Liver and Colon

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03137706

Enrollment

Registered

2017-05-03

Start date

2016-11-14

Completion date

2020-10-19

Last updated

2021-04-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Carcinoma, Liver and Intrahepatic Bile Duct Carcinoma, Pancreatic Carcinoma

Brief summary

This pilot research trial studies characterization of mechanical tissue properties in patients with pancreatic, liver, or colon cancer. Mechanical properties and stiffness of the cancerous tissue may be correlated with the standard pathology report that describes the stage of the disease.

Detailed description

PRIMARY OBJECTIVES: I. To determine if our optical polarimeter device is able to measure tissue stiffness across several human cancer types ex vivo. SECONDARY OBJECTIVES: I. To describe the inter- and intra-tumor heterogeneity of tissue stiffness. II. To determine if the measurements made by the optical polarimeter device are non-destructive. TERTIARY OBJECTIVES: I. Perform multi-variable cross-correlation statistical analysis to determine relationships between: tissue stiffness characteristics, molecular level signatures, and cellular level properties, and if numbers permit, response to treatment. OUTLINE: Patients undergo fresh tumor tissue collection at the time of surgery. The fresh tumor tissue samples are analyzed for tissue stiffness measurements using an optical polarimeter device and cell viability using an automated cell counter.

Interventions

PROCEDUREBiospecimen Collection

Undergo fresh tumor tissue collection

OTHERLaboratory Biomarker Analysis

Correlative studies

OTHERLaboratory Procedure

Tissue stiffness and cell viability analysis

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Scheduled for surgery to remove primary tumors in the pancreas, liver or colon and have not undergone any prior treatment * Ability to understand and the willingness to sign a written informed consent

Exclusion criteria

* Pregnant women will not be consented * Patients that are unable to consent for surgery * Primary liver tumors with cirrhosis will be excluded from this study

Design outcomes

Primary

Measure	Time frame	Description
Young's modulus (stiffness) on fresh tissue	Up to 15 months	A portable optical fiber polarimetric sensor device to measure the Young's modulus in tissue samples will be used.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026