Combined Use of Multiple Biomarkers With Stress Testing to Detect Coronary Artery Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03137550

Acronym

COMBAT-CAD

Enrollment

850

Registered

2017-05-02

Start date

2017-04-12

Completion date

2022-04-30

Last updated

2022-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Brief summary

Main aim of the COMBAT-CAD-Study is to clarify, if the combination of stress testing with biomarkers improves the diagnostic accuracy. Hypothesis of our study is that diagnosis of CAD can be improved by adding biomarkers to solely stress testing for the workup of patients with suspected CAD or progress of already known CAD.

Detailed description

The COMBAT-CAD Study is an observational study with the aim to improve the diagnostic accuracy by a combination of stress testing with sensitive and specific biomarkers in detecting coronary artery disease or its progress. The main subjects are all patients with CAD or suspicion of CAD sent to the University Heart Center Hamburg. In these patients, ECG, laboratory examination, symptoms or transthoracic echocardiography in rest could not rule out CAD or progress of known CAD. The hypothesis of the study is that detection of CAD can be improved by adding biomarkers to stress testing for the diagnostic workup of patients with suspected CAD or progress of already known CAD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1\. Every patient referred to coronary angiography, or diagnostic work-up with suspicion of CAD or progress of CAD (in case of CABG patients or already treated with PCI)

Exclusion criteria

1. Insufficient knowledge of the German language (able to understand and write the German language) 2. Physical or psychological incapability to take part in the investigation 3. Persons with no sufficient language ability in German to understand the provided study information material.

Design outcomes

Primary

Measure	Time frame	Description
Diagnosis of coronary artery disease	Within the initial diagnostic evaluation process (maximum within 30 days)	The diagnosis of coronary artery disease through stress testing alone and combined with cardiac biomarkers.

Countries

Germany

Outcome results