Evidence-based Screening Strategies for Celiac Disease

Improving Case-finding Strategies for Celiac Disease in Family Members: a Follow-up Study

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03136731

Enrollment

3517

Registered

2017-05-02

Start date

2017-11-29

Completion date

2032-12-31

Last updated

2023-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Celiac Disease

Keywords

Celiac disease, Gluten, Microbiome, Genetic

Brief summary

Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.

Detailed description

The current project will result in the identification of genetic, environmental or downstream biomedical markers that predict the development of celiac disease at the individual level. Moreover, the markers can be exploited in prediction of specific disease risks, manifestations, comorbidities and complications.

Interventions

DIAGNOSTIC_TESTCeliac disease antibody screening

Observational parameters

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 100 Years

Healthy volunteers

Yes

Inclusion criteria

* Cohort 1: Family member of celiac disease patient * Cohort 2: Previously diagnosed celiac disease

Exclusion criteria

* Cohort 1: No previous celiac disease * Cohort 2: Celiac disease diagnosis not confirmed

Design outcomes

Primary

Measure	Time frame	Description
Forthcoming celiac disease diagnosed by current diagnostic criteria	With in 10 years	Assessed by positive transglutaminase antibodies, small bowel mucosal villous atrophy

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026