Hypoperfusion in Newborn, Hypotension, Infant, Premature, Necrotizing Enterocolitis of Newborn, Oliguria, Sepsis Newborn
Conditions
Brief summary
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants. It includes near-infrared spectroscopy (NIRS), pulse oximetry with perfusion index (PI) and pleth variability index (PVI) and functional echocardiography.
Detailed description
Hemodynamic observational comparisons will be performed in 6 episodes below on each patient. 1. first 24 hours after birth 2. during red blood cell (RBC) transfusion: from 4 hours before to 4 hours after the transfusion 3. suspicion of necrotizing enterocolitis: from the suspicion point for 48 hours 4. suspicion of sepsis: from the suspicion point for 48 hours 5. oligouria (\< 1 mL/kg/hour of urine): for 48 hours 6. hypotension (mean blood pressure \< 30 mmHg): for 48 hours
Interventions
DEVICENIRS (near Infra-red spectroscopy)
1. NIRS, INVOS 5100 cerebral/somatic oximeter monitor (Somanetics Corp, Troy, Michigan, USA) 2. Radical-7 pulse oximeter (Masimo Corp, Irvine, CA, USA) 3. Echocardiography (Phillips HD 15 Ultrasound system, CA, USA)
Sponsors
Inha University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Months
Healthy volunteers
No
Inclusion criteria
* premature infants with 32 weeks or less of gestational age or 1,500 g or less of birth weight
Exclusion criteria
* infants without the consent of their guardians
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Positive predictive value of each index on hypotension | first 24 hours after birth | Positive predictive value of each index which are recorded through the monitoring machines |
Countries
South Korea
Outcome results
None listed