Infertility, Female
Conditions
Brief summary
Polycystic ovary syndrome accounts for the vast majority of anovulatory symptoms and hyperandrogenism in women. The diagnosis of Polycystic ovary syndrome has life-long implications, with increased risk for infertility, metabolic syndrome, and type 2 diabetes mellitus, and possibly for cardiovascular disease and endometrial carcinoma. Polycystic ovary syndrome is diagnosed in adolescents with otherwise unexplained, persistent hyperandrogenic anovulatory symptoms that are inappropriate for age and stage of adolescence. It should be considered in any adolescent girl with a chief complaint of hirsutism, treatment-resistant acne, menstrual irregularity, acanthosis nigricans, and/or obesity
Interventions
DRUGletrozole plus metformin
letrozole 5 milligram tablets plus metformin 850 milligram tablets
DRUGletrozole
letrozole 5 milligram tablets
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* polycystic ovaries patients who had failed to become pregnant after 3 courses of 150 mg of clomiphene citrate (considered as clomiphene resistant),whereas the value of the above mentioned investigation are normal.
Exclusion criteria
1. women with other causes of infertility as male factor,tubal factor,those with endocrine disorders as thyroid dysfunction and hyperprolactinemia. 2. women who received hormonal treatment or ovulation induction drugs in the last 3 months before the study. 3. women with history of liver,kidney or cardiovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ovulation rate | 14 days |
Countries
Egypt
Outcome results
None listed