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Hybrid Exercise Training for Weight Loss

The Effects of a Novel Hybrid Exercise Training Program on Body Composition, Body Weight and Energy Balance in Sedentary Overweight/Obese Women

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03134781
Acronym
DoIT
Enrollment
49
Registered
2017-05-01
Start date
2015-07-31
Completion date
2017-04-30
Last updated
2021-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body Composition, Circuit-based High Intensity Interval Training, Habitual Physical Activity, Performance, Resting Metabolic Rate

Brief summary

In this study the investigators utilized a novel hybrid HIIT (high intensity interval training) exercise training approach, the Hybrid Interval Training (DoIT) workout that combines interval training, resistance exercise training and functional training in order to test the hypothesis that DoIT will be able to: i) reduce body mass, ii) improve body composition and iii) alter energy balance, of previously inactive, overweight/obese women.

Detailed description

In a controlled randomized, two-group, repeated measures design, 65 healthy, sedentary, premenopausal overweight or obese women were randomly assigned to one of three groups: (a) a control group (C, N=21) that participated only in measurements, (b) a training group (TR, N=14) that participated in a supervised 40-week DoIT workout exercise training program and (c) a training-detraining group (TRD, N=14). During the first 20 weeks, TR and TRD followed exactly the same training protocol. At the end of this period, TR continued training for 20 more weeks whereas TRD terminated training for 20 weeks (detraining). Anthropometric, metabolic, daily nutritional intake, habitual physical activity and performance measurements were performed in all groups at baseline, at 20 weeks and 40 weeks.

Interventions

BEHAVIORALDoIT workout

A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training and performed according to a periodized model of exercise prescription as an alternative approach for weight management. FFIT was performed 3 times/week with 48 hours recovery between sessions for 40 weeks.

BEHAVIORALDoIT workout - Detraining

A hybrid small-group (5-10 women/session) training modality, that combines interval training, resistance exercise and functional training, performed according to a periodized model of exercise prescription for a 20-week period (3 times/week). Immediately after a 20-week detraining period (no training was performed) was followed.

BEHAVIORALControl - No training

No training was performed during a 40-week period. Participation only in measurements.

Sponsors

University of Thessaly
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
30 Years to 45 Years
Healthy volunteers
Yes

Inclusion criteria

* (a) were sedentary (\<7,500 steps/day; VO2max \<30 ml/kg/min), b) premenopausal women aged 30-45 years, c) were overweight or obese class 1 (BMI=25-34.9 kg/m2), d) were non-smokers for ≥6 months before the study, e) not following a diet intervention or using nutritional supplements/medications before (≥6 months) and during the study, f) had no weight loss greater \>10% of body mass ≤6 months before the study, g) participated in ≥80% of total exercise sessions, and h) had no symptoms of depression.

Exclusion criteria

* a) a recent febrile illness, b) history of muscle lesion, c) lower limb trauma, d) signs, symptoms or diagnosis of serious health complications or physical disability or other medical condition compromising safe participation in exercise training.

Design outcomes

Primary

MeasureTime frameDescription
Change in fat-free massAt baseline, at 20 weeks and at 40 weeks.Fat-free mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in waist circumferenceAt baseline, at 20 weeks and at 40 weeks.
Change in hip circumferenceAt baseline, at 20 weeks and at 40 weeks.
Change in waist-to-hip ratioAt baseline, at 20 weeks and at 40 weeks.
Change in body fat.At baseline, at 20 weeks and at 40 weeks.Body fat assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in fat massAt baseline, at 20 weeks and at 40 weeks.Fat mass assessed by whole-body dual-energy X-ray absorptiometry (DXA).
Change in resting metabolic rateAt baseline, at 20 weeks and at 40 weeks.Measured using a portable open-circuit indirect calorimeter with a ventilated hood system.
Change in exercise-induced caloric expenditure.At baseline, at 20 weeks and at 40 weeks.Measured using a portable indirect calorimetry system
Change in body massAt baseline, at 20 weeks and at 40 weeks.
Change in body mass indexAt baseline, at 20 weeks and at 40 weeks.

Secondary

MeasureTime frameDescription
Change in maximal oxygen consumption (VO2max)At baseline, at 20 weeks and at 40 weeks.Assessed by a portable open-circuit spirometry system.
Change in blood lactate concentrationPre-exercise, during the exercise and post-exercise at baseline, at 20 weeks and at 40 weeks.
Change in habitual physical activityAt baseline, at 20 weeks and at 40 weeks.Seven-day habitual physical activity was assessed by accelerometry
Change in dietary intakeAt baseline, at 20 weeks and at 40 weeks.Assessed using 7-day diet recalls
Change in maximal strength (1RM)At baseline, at 20 weeks and at 40 weeks.Measured bilaterally on a horizontal leg press.

Countries

Greece

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 23, 2026