Preoperative Anxiety at Oocyte Retrieval

The Effect of Preoperative Anxiety With Depth of Anesthesia During Oocyte Retrieval on IVF Success

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03134651

Enrollment

131

Registered

2017-05-01

Start date

2014-07-24

Completion date

2016-09-24

Last updated

2017-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia Awareness, Anxiety State, Infertility, Female

Keywords

Anxiety, Oocyte retrieval, Monitoring of brain function

Brief summary

This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half high-anxiety group.

Detailed description

Anxiety is common among women hospitalized for oocyte retrieval. Infertility is usually accompanied by psychological and behavioral changes and can result in preoperative anxiety. Sometimes, preoperative anxiety can be serious. Furthermore, in the absence of premedication for oocyte retrieval, severe degrees of anxiety may occur. Anxiety effects the total consumption of analgesic and anesthetic drugs intraoperatively and has a negative impact on recovery from anesthesia. In addition, the negative effect of anesthetic agents used on fertilization and embryo quality during in vitro fertilization (IVF) has been discussed. However, the impact of any of them on fertilization and embryo quality has not been clearly determined to date. Studies have reported different results regarding the negative effects of anesthetic agents on embryo development and fertilization.

Interventions

DEVICEMonitoring brain function

DRUGpropofol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Age

25 Years to 43 Years

Healthy volunteers

Yes

Inclusion criteria

* oocyte retrieval under sedation * 25 and 43 years of age * American Society of Anesthesiologists physical status I-II

Exclusion criteria

* history of psychiatric illness * secondary infertility can be surgically corrected * not able to communicate well in the native language * those women who necessitated general anesthesia

Design outcomes

Primary

Measure	Time frame	Description
Changes in perioperative Monitoring brain function were measured	Preoperative, intraoperative and postoperative first minute	Monitoring brain function was assessed Change from baseline at preoperatively, intraoperative 5th and 15th minutes and after anesthesia

Secondary

Measure	Time frame	Description
pregnancy rate	10 days	pregnancy rate

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026