Kidney Transplantation, Rejection Acute Renal
Conditions
Keywords
metabolomics, biomarker, acute rejection
Brief summary
The development of acute rejection can only be considered in cases with increasing serum creatinine in patients with kidney transplantation. However, the serum creatinine itself is not specific but also accurate for detection of acute rejection. So The specific biomarker is required for acute rejection of kidney transplant. In this study, the investigators will enroll 200 consecutive kidney transplant patients in Seoul National University Hospital and follow up. Serial collection of urine and serum will be done. Acute rejection specific urine metabolite will be found by LC MS/MS.
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Kidney transplant patients in Seoul National University Hospital * Patients with triple maintenance immunosuppression including Tacrolimus, mycophenolate and steroid
Exclusion criteria
* History of other organ transplantation * ABOi and/or crossmatch(+) transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| biomarker for acute rejection in kidney transplantation | 1 year | urine metabolite which is specific for kidney transplant rejection |
Countries
South Korea
Contacts
Primary ContactJongwon Ha, MD, PhD
Outcome results
None listed