Cancer Patient
Conditions
Keywords
Regional nerve block, cancer recurrence
Brief summary
It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.
Detailed description
1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms. 2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.
Interventions
OTHERNormal saline
Injection of Normal saline around peripheral nerve
OTHERperipheral Nerve block
Injection of local anesthetics around peripheral nerve
Sponsors
Luo Foquan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
the patients in treatment group will received reginoal nerve block with 0.35% Ropivacane and 0.5% lidocaine in normal saline under ultrasound guide, while those in control group received equal volume of normal saline.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with primary cancer undergoing elective surgery under general anesthesia
Exclusion criteria
* Disagree to participate，drop out,lose track, infectious abdominal wall，abnormal puncture point，coagulation dysfunction，allergy of local anesthetic ，immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the effect of nerve block on the cancer recurrence rate and survival rate postoperation | up to 5 years after surgery | to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dosage of intraoperative anesthetic | intraoperative period | Record the propofol and remifentanil during the operation |
| the effect of nerve block on the percentage and classification of immunocyte and content of cytokines | at 0h, 24h, 48h after nerve block | percentage and classification of immunocyte will be detected by Use flow cytometry, and cytokines will be detected by ELISA |
| VAS after operation | at 24h, 48h after nerve block | Assess the visual analogue scale 24，48h after nerve block |
| activity after operation | up to 2 weeks | Observe recovery time of gastrointestinal function and off-bed activity after nerve block |
| Hospital stay | up to 4 weeks after surgery | Observe length of hospital stay |
Countries
China
Outcome results
None listed