Lung Collapse
Conditions
Brief summary
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.
Interventions
PROCEDUREDP-PEEP
PEEP titration trial for the lowest DP after the alveolar recruitment maneuver
PROCEDURERM-5
Fixed standard PEEP after the alveolar recruitment maneuver
Sponsors
Fundación para la Investigación del Hospital Clínico de Valencia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Non-obese patients scheduled for cardiac surgery (CABG and valve replacement)
Exclusion criteria
* i) age \<18yr or \>80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index \>35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| driving pressure | intraoperative | The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pulmonary complications | 72 first postoperative hours | The most frequent postoperative pulmonary complications will be recorded (acute respiratory failure, pneumonia, atelectasis, need of ventilatory support, acute respiratory distress syndrome) |
Countries
Spain
Outcome results
None listed