Jaundice and Sepsis in Neonates
Conditions
Brief summary
Ceftriaxone is an antibiotic often used for the management of sepsis. Neonates commonly have jaundice during the first postnatal week. Ceftriaxone will be given as standard of care for sepsis and investigators will observe the effect on jaundice.
Interventions
DRUGceftriaxone
Eligible infants will receive ceftriaxone as standard of care for sepsis
Sponsors
University of Rochester
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
3 Days to 7 Days
Healthy volunteers
No
Inclusion criteria
* Term infants with sepsis requiring IV antibiotics for more than 3 days and who has total serum bilirubin 6-12 mg/dL and resolving by day 4 of life.
Exclusion criteria
* Infants with asphyxia (Apgar score \<3 at 5 minutes), chromosomal disorder, failed hearing test at baseline, family history of hearing loss, unconjugated hyperbilirubinemia requiring phototherapy, TORCH infection, craniofacial malformations, listeria monocytogenes infection, and any clinical conditions which will preclude discharge to home.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in bilirubin binding assays | baseline and through study completion, an average of 1 hour |
Secondary
| Measure | Time frame |
|---|---|
| Automated brain stem evoke response test | through study completion, an average of 1 hour |
Countries
United States
Outcome results
None listed